TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus

TRPV4 antagonists ameliorate ventriculomegaly in a rat model of hydrocephalus

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Hydrocephalus is a serious condition Urological Supplies that impacts patients of all ages.The standards of care are surgical options to divert, or inhibit production of, cerebrospinal fluid; to date, there are no effective pharmaceutical treatments, to our knowledge.The causes vary widely, but one commonality of this condition is aberrations in salt and fluid balance.

We have used a genetic model of hydrocephalus to show that ventriculomegaly can be alleviated by inhibition of the transient receptor potential vanilloid 4, a channel that is activated by changes in osmotic balance, temperature, pressure and inflammatory mediators.The TRPV4 antagonists do not appear to have adverse effects on whey protein isolado e hidrolisado the overall health of the WT or hydrocephalic animals.